<p>Chapter 1 - Heart physiology and heart diseases, Djordje Jakovljevic, Nenad Filipovic.- Chapter 2 - Finite element modeling, Nenad Filipovic.- Chapter 3 - System biology modeling for drug optimization, Marko Zivanovic, Nenad Filipovic.- Chapter 4 - Artificial intelligence approach for medical image processing, Tijana Sustersic, Nenad Filipovic.-Chapter 5 - Pharmacokinetic and AI modeling, Lazar Velicki, Nenad Filipovic.- Chapter 6 - Molecular micro modeling of heart muscle, Momcilo Prodanovic, Nenad Filipovic.- Chapter 7 - Use case: Risk stratification of cardiomyopathy disease, Lazar Dasic, Nenad Filipovic.- Chapter 8 - Use case: Surrogate AI model for left ventricle modeling, Bogdan Milicevic, Nenad Filipovic.- Chapter 9 - Use case: Carotid artery plaque modeling, Andjela Blagojevic, Nenad Filipovic.- Chapter 10 - Use case: Stent deployment for coronary artery, Miljan Milosevic, Nenad Filipovic.- Chapter 11 - Use case: Balloon deployment for peripheral arteries. Aleksandra Vulovic, Nenad Filipovic.- Chapter 12 - Use case: Aorta stenosis modeling, Smiljana Tomasevic, Nenad Filipovic.- Chapter 13 - Use case: Stent biodegradation modeling, Dalibor Nikolic, Nenad Filipovic.</p>